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本文采用傅里叶变换红外光谱法与中红外光纤及ATR探头联用,首次实现了肿瘤组织的在体原位检测,即在有血液循环的活体组织中获得了具有很好信噪比的中红外光谱。实验结果表明在体原位的正常和肿瘤组织的光谱特征同我们先前液氮冰冻样品以及新鲜离体检测的结果是相似的,即符合液氮和新鲜离体样品研究中所得到的鉴别癌症与正常组织光谱变化规律,例如图1所列出的肠癌的原位在体光谱,与离体癌变组织光谱相似,这一创新结果表明中红外光纤-红外光谱仪联用可能发展成一种外科手术中无损、快速、准确的在体检测的方法。
In this paper, the use of Fourier transform infrared spectroscopy with the mid-infrared fiber and ATR probe combined for the first time in situ detection of tumor tissue in vivo, that is, have a good blood circulation in vivo tissue with good signal to noise ratio IR. The experimental results show that the spectral characteristics of normal and tumor tissues in situ are similar to those of our previous liquid nitrogen frozen samples and fresh in vitro assays that are consistent with the results obtained from liquid nitrogen and fresh in vitro sample studies to identify The normal tissue spectral changes, such as the in situ on-body spectra of colorectal cancer listed in Figure 1, are similar to the in vitro cancerous tissue spectra and this innovative finding suggests that the combination of mid-infrared fiber-infrared spectroscopy may develop into a surgical procedure Non-destructive, rapid and accurate method of in vivo testing.