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目的:探讨妊娠早期、晚期妇女HR-HPV感染的情况与宫颈病变的关系。方法:采用二代杂交捕获法(HC-Ⅱ)对100例妊娠早期、妊娠晚期及产后42天妇女进行高危型人乳头瘤病毒(HR-HPV)检测,对HR-HPV阳性者进行宫颈脱落细胞薄层液基细胞学检查。结果:妊娠早期HR-HPV感染率为21%,妊娠晚期HR-HPV感染率为46%,产褥期HRHPV感染率为17%,妊娠晚期感染率明显高于妊娠早期(P<0.05),产后42天HR-HPV感染率最低(P<0.05)。各期薄层液基细胞学检查结果比较差异无统计学意义(P>0.05)。结论:通过研究发现妊娠期HR-HPV感染率随妊娠进展而升高,应重视孕期宫颈病变的检查及产后随访,及早发现HR-HPV的持续性感染。
Objective: To investigate the relationship between HR-HPV infection and cervical lesions in early pregnancy and late pregnancy. Methods: A total of 100 women with early pregnancy, late pregnancy and 42 days postpartum were tested for high-risk human papillomavirus (HR-HPV) by second generation hybridization capture method (HC-Ⅱ) Thin-layer liquid-based cytology. Results: HR-HPV infection rate was 21% in early pregnancy, HR-HPV infection rate in late pregnancy was 46% and postpartum HRHPV infection rate was 17%. The infection rate in late pregnancy was significantly higher than that in early pregnancy (P <0.05) HR-HPV infection rate was the lowest (P <0.05). The results of thin-layer liquid-based cytology showed no significant difference (P> 0.05). Conclusion: Through the study found that HR-HPV infection rate during pregnancy increased with the progress of pregnancy should pay attention to pregnancy cervical lesions and postpartum follow-up, and early detection of persistent HR-HPV infection.