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肿瘤的恶性表型侵袭和转移是治疗中最棘手的问题之一。随着肿瘤的侵袭转移等生物学行为研究的深入 ,包括肿瘤细胞粘附于基质 -蛋白水解酶降解基质 -肿瘤细胞移行等过程。越来越多的证据表明多种粘附分子尤其是E钙粘蛋白 (E -cad)与肿瘤的侵袭转移有着密切的关系。1 E -cad生物
Malignant tumor invasion and metastasis is one of the most intractable problems in the treatment. With the invasion and metastasis of tumors and other biological behavior of the in-depth study, including tumor cell adhesion to matrix - proteolytic enzyme degradation matrix - tumor cell migration process. More and more evidences show that a variety of adhesion molecules, especially E-cadherin, have a close relationship with tumor invasion and metastasis. 1 E-cad creature