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肾小球肾炎是一种多发性自身免疫性疾病,主要与免疫介导的炎症反应有关,许多细胞因子在肾小球肾炎的病理反应中起重要作用。随着分子免疫与分子生物学技术的发展,对细胞因子的研究不断深入,在细胞因子网络调节中,致炎性细胞因子与抗炎性细胞因子的相互作用可能决定了免疫介导的炎症性疾病的发生与发展。其中抗炎性细胞因子如白细胞介素IL-10、IL-13与IL-1受体拮抗剂等担负了重要的作用,它们通过抑制其它炎症性介质的产生而发挥抗炎效应,从而维持机体免疫系统的平衡,防止炎症因子产生过多
Glomerulonephritis is a multiple autoimmune disease that is primarily associated with immune-mediated inflammatory responses and that many cytokines play an important role in the pathological response to glomerulonephritis. With the development of molecular immunity and molecular biology techniques, the research on cytokines continues to deepen. In the regulation of cytokines network, the interaction between inflammatory cytokines and anti-inflammatory cytokines may determine immune-mediated inflammation The occurrence and development of diseases. Anti-inflammatory cytokines such as interleukin IL-10, IL-13 and IL-1 receptor antagonists play an important role, they play an anti-inflammatory effect by inhibiting the production of other inflammatory mediators, thereby maintaining the body The balance of the immune system prevents excessive production of inflammatory cytokines