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目的观察小剂量三苯氧胺联合桂枝茯苓胶囊治疗乳腺增生症对患者血清性激素水平的影响。方法选取兴隆县人民医院2012年10月-2014年10月收治的乳腺增生症女性患者200例,随机分为观察组和对照组各100例,观察组给予小剂量三苯氧胺联合桂枝茯苓胶囊治疗,对照组单纯给予桂枝茯苓胶囊治疗。治疗后比较2组血清性激素水平,包括雌二醇(E2)、孕酮(P)及黄体生成素(LH)水平。结果与治疗前比较,治疗后2组患者血清E2水平降低,血清P及LH水平均升高,且观察组血清E2、P及LH水平变化幅度大于对照组,差异均有统计学意义(P<0.05)。结论小剂量三苯氧胺联合桂枝茯苓胶囊治疗乳腺增生症可显著改善血清性激素水平,具有临床推广应用价值。
Objective To observe the effect of low dose tamoxifen combined with Guizhi Fuling capsule on serum sex hormone levels in patients with hyperplasia of mammary glands. Methods 200 cases of breast hyperplasia female patients admitted from October 2012 to October 2014 in Xinglong County People’s Hospital were randomly divided into observation group and control group with 100 cases in each. The observation group was treated with low dose of tamoxifen and Guizhi Fuling capsule, The control group was treated with Guizhifuling Capsule alone. After treatment, the levels of serum sex hormones including estradiol (E2), progesterone (P) and luteinizing hormone (LH) were compared. Results Compared with those before treatment, serum E2 level and serum P and LH levels increased in both groups after treatment, and the changes of serum E2, P and LH levels in the observation group were significantly greater than those in the control group (P < 0.05). Conclusion Low dose of tamoxifen combined with Guizhi Fuling capsule treatment of breast hyperplasia can significantly improve serum sex hormone levels, with clinical application value.