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目的探讨C反应蛋白(CRP)与2型糖尿病(T2DM)患者颈动脉内膜中层厚度(IMT)之间的关系。方法对55例T2DM患者及35例正常对照人群应用免疫比浊终点法测定超敏C反应蛋白(hs-CRP),B型超声检查测定颈动脉IMT,并测定各临床、生化参数。结果(1)T2DM组CRP水平高于正常对照组〔(2.85±3.03)(0.85±0.80)mg/L,P<0.01〕;(2)T2DM组IMT为(0.96±0.38)mm,对照组IMT为(0.65±0.14)mm,2组比较差异有统计学意义(P<0.01);(3)Logistic回归分析显示,CRP是T2DM患者IMT增厚的危险因素(P<0.05,OR=1.244,95%CI为1.017～1.522)。结论hs-CRP与T2DM患者颈动脉IMT增厚有关。
Objective To investigate the relationship between C-reactive protein (CRP) and carotid artery intima-media thickness (IMT) in type 2 diabetes mellitus (T2DM). Methods Serum hs-CRP was measured by immunoturbidimetry in 55 cases of T2DM and 35 normal control subjects. The carotid IMT was measured by B-mode ultrasonography and the clinical and biochemical parameters were measured. (2) The IMT of T2DM group was (0.96 ± 0.38) mm and the level of IMT in T2DM group was (2.85 ± 3.03) (0.85 ± 0.80) mg / L, (0.65 ± 0.14) mm, the difference between the two groups was statistically significant (P <0.01). (3) Logistic regression analysis showed that CRP was a risk factor for IMT thickening in T2DM patients (P <0.05, OR = 1.244, % CI 1.017 ~ 1.522). Conclusions hs-CRP is associated with thickening of carotid IMT in T2DM patients.