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目的:研究大肠癌中MMP-2、MMP-9与IV型胶原的表达及其相关性。方法:对30例Dukes’B、C期大肠癌患者的癌组织和正常组织进行IV型胶原、MMP-2、MMP-9的免疫组织化学检测,并进行相关性分析。结果:IV型胶原在大肠癌组织中的表达明显降低;MMP-2、MMP-9在大部分正常大肠组织中均未见表达,仅少数见到有阳性表达,而在癌组织中表达明显增强。IV型胶原评分与MMP-9表达之间呈负相关。结论:大肠癌组织中IV型胶原的表达明显降低,MMP-9对大肠癌中IV型胶原的降解起着重要作用。
Objective: To study the expression and correlation of MMP-2, MMP-9 and type IV collagen in colorectal cancer. Methods: Immunohistochemical detection of type IV collagen, MMP-2 and MMP-9 in 30 cases of Dukes’B and C colorectal cancer tissues and their normal tissues were performed and their correlation was analyzed. Results: The expression of type IV collagen in colorectal carcinoma was significantly decreased. The expression of MMP-2 and MMP-9 in most of the normal colorectal tissues was not seen, only a few positive expression was found, while the expression was significantly enhanced in the cancerous tissue . There was a negative correlation between type IV collagen score and MMP-9 expression. CONCLUSION: The expression of type IV collagen in colorectal carcinoma is significantly reduced, and MMP-9 plays an important role in the degradation of type IV collagen in colorectal carcinoma.