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目的:探讨治疗复发性外阴阴道假丝酵母菌病(RVVC)的有效方法。方法:选择2007年1月～2009年1月舟山市妇幼保健院门诊就诊的345例RVVC妇女,用两种(口服+外用)药物强化+巩固治疗方案治疗,每月1个疗程。口服用药:伊曲康唑200 mg,2次/d,连用3天或氟康唑150 mg,顿服,3天后重复1次。阴道用药:咪康唑栓400 mg,每晚1次,连用6天或克霉唑栓100 mg,每晚1次,连用7天或克霉唑栓500 mg,3天后重复1次。症状消失伴真菌学检查转阴后再巩固治疗6个疗程。结果:RVVC治疗有效率为89.9%;停药后3、6个月远期治愈率分别为82.6%和72.5%。结论:选择两种药物(口服+外用)强化+巩固治疗是治愈RVVC的有效措施。
Objective: To explore effective methods for the treatment of recurrent vulvovaginal candidiasis (RVVC). Methods: A total of 345 RVVC outpatients from January 2007 to January 2009 in Zhoushan Maternal and Child Health Care Hospital were enrolled in this study. They were treated with two kinds of drugs (oral + topical) to reinforce and consolidate the treatment regimen, one course per month. Oral medication: itraconazole 200 mg, 2 times / d, once every 3 days or fluconazole 150 mg, Dayton clothes, repeated 1 day after 3 days. Vaginal drug: miconazole suppository 400 mg, night 1, once every 6 days or clotrimazole suppository 100 mg, night 1, once every 7 days or clotrimazole suppository 500 mg, repeated 3 days after 1. Symptoms disappear with fungal examination turned negative and then consolidate the treatment of 6 courses. Results: The effective rate of RVVC treatment was 89.9%. The long-term cure rates of 3 and 6 months after drug withdrawal were 82.6% and 72.5% respectively. Conclusion: The two drugs (oral + external use) to strengthen + consolidation therapy is an effective measure to cure RVVC.