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目的系统评价中国女性雌激素受体α(estrogen receptorα,ER-α)基因第1内含子XbaⅠ位点多态性与子宫内膜异位症(endometriosis,EM)的相关性。方法计算机检索PubMed、MEDLINE、e Cochrane Library(2012年第3期)、VIP、CBM、WanFang Data和CNKI,收集国内外关于ER-α基因第1内含子XbaⅠ位点多态性与子宫内膜异位症相关性的病例-对照研究,检索时限均从1980年至2012年。由2位评价者根据纳入与排除标准独立筛选文献、提取资料并评价质量后,采用RevMan 5.0和Stata 12.0软件进行Meta分析,采用Egger’s线性回归法分析发表偏倚。结果最终纳入7个研究,包括EM患者676例及健康对照688例。Meta分析结果显示:对于中国女性,基因型X/X人群的EM发病风险与基因型x/x人群[OR=0.95,95%CI(0.58,1.54),P=0.82]及基因型X/x人群[OR=0.73,95%CI(0.44,1.20),P=0.22]均相当,并且等位基因X人群的EM发病风险与等位基因x人群相当[OR=1.11,95%CI(0.93,1.33),P=0.25]。结论目前尚未发现ER-α基因第1内含子XbaⅠ位点基因型和等位基因X与中国女性EM发病风险相关。受纳入研究数量及质量所限,上述结论尚待开展更多研究加以验证。
Objective To systematically evaluate the association between Xba Ⅰ site polymorphism of estrogen receptor α (ER-α) gene and endometriosis (EM) in Chinese women. Methods The PubMed, MEDLINE, eCochrane Library (2012No. 3), VIP, CBM, WanFang Data and CNKI were searched by computer. The polymorphism of XbaⅠ locus in endometrium of ER- Etiology-related case-control study, retrieval time from 1980 to 2012. Two reviewers independently screened the literature based on inclusion and exclusion criteria, extracted data and assessed quality. Meta-analysis was performed using RevMan 5.0 and Stata 12.0 software, and Egger’s linear regression analysis of publication bias. Results The final study included 7 studies, including 676 EM patients and 688 healthy controls. Meta-analysis showed that for Chinese women, the risk of developing EM in genotype X / X population was significantly higher than that in genotype x / x population [OR = 0.95,95% CI (0.58,1.54), P = 0.82] and genotype X / (OR = 0.73, 95% CI, 0.44, 1.20, P = 0.22), and the risk of developing EM in allele X was comparable to allele x (OR = 1.11, 95% CI, 1.33), P = 0.25]. Conclusion The genotype and allele X at the first intron of ER-α gene have not been found to be associated with the risk of EM in Chinese women. Due to the limited number and quality of studies involved, more research is yet to be done to verify these conclusions.