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人体受寄生虫感染过程中,血清中IgE的含量增加,有时甚至明显增加。某些寄生虫病的临床表现可为免疫-变态反应所致的症状,如蛔虫病时的吕弗氏综合症、某些内脏寄生虫病时的哮喘样呼吸困难和搔痒性红斑或荨麻疹、包虫病囊肿破裂所致的过敏性休克等。以速发型过敏反应为基础的皮肤试验已广泛地应用于寄生虫病的病原诊断。嗜酸粒细胞增多则为诊断蠕虫感染很有启示性的标志,而嗜酸粒细胞又往往与IgE含量有相关性。但蠕虫感染时不能单凭IgE或反应素抗体的含量来估计速发型免疫-变态反应的发生率及其严重程度;流行地区的寄生虫感染与环境变态反应之间存在负相关性;相反在某些情况下控制良好的过敏反应又可加强机体防御寄生虫的能力,而这种过敏反应却又是寄生虫所激发的;在血吸虫感染时,还发现过敏性抗体与免疫效应细胞之间存在合作关系。
In the course of human infection by parasite, the content of IgE in serum increases, and sometimes even increases obviously. The clinical manifestations of certain parasitic diseases may be those caused by immune-allergic reactions such as Lupus & apos; s syndrome at the time of ascariasis, asthma-like dyspnea and pruritic erythema or urticaria at certain parasitic parasites, Echinococcosis cystic rupture caused by anaphylactic shock and so on. Skin tests based on immediate hypersensitivity reactions have been widely used in the diagnosis of parasitic diseases. Eosinophilia is a very diagnostic indicator of helminth infection, and eosinophils are often associated with IgE levels. However, the prevalence and severity of immediate-onset immune-allergic reactions can not be estimated solely on the basis of IgE or reactive antibody levels in worms; negative correlation exists between parasitic infections in endemic areas and environmental allergies; on the contrary, Well-controlled allergic reactions in some cases enhance the ability of the body to defend parasites, which are provoked by parasites; there is also cooperation between allergic antibodies and immune effector cells during schistosomiasis infection relationship.