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目的探讨持续小剂量伐地那非联合曲唑酮并配合心理行为治疗早泄的临床疗效。方法136例早泄患者随机分为实验组(小剂量伐地那非+曲唑酮+行为疗法)和对照组(曲唑酮+行为疗法),记录治疗前后阴道内射精潜伏期(IELT)并进行组内和组间比较,同时记录夫妻对性生活的满意情况。结果治疗前,实验组和对照组IELT分别为(0.87±0.29)min、(0.93±0.35)min,治疗后分别为(4.62±2.3 1)min、(2.35±1.25)min,差异有统计学意义(P<0.0 1),且实验组IELT较对照组相比差异有统计学意义(P<0.01)。夫妻双方对性生活的情况:实验组满意率(62.3%)和总满意率(满意加基本满意)(89.8%)分别优于对照组满意率(37.3%)和总满意率(67.2%),差异均有统计学意义(P<0.01)。结论持续小剂量伐地那非联合曲唑酮并配合心理行为治疗早泄在延长IELT,改善夫妻双方性生活满意度方面明显优于盐酸曲唑酮配合心理行为疗法组,持续小剂量给药可以起到增强疗效和降低副作用,两药合用在治疗早泄方面有一定的应用前景。
Objective To investigate the clinical efficacy of continuous low dose vardenafil combined with trazodone in combination with psychological behavior for premature ejaculation. Methods One hundred and sixty-six patients with premature ejaculation were randomly divided into experimental group (low-dose vardenafil + trazodone + behavioral therapy) and control group (trazodone + behavioral therapy). The intravaginal ejaculation latency (IELT) Intra-and inter-group comparison, while recording the couple’s sexual satisfaction. Results Before treatment, the IELT in the experimental group and the control group were (0.87 ± 0.29) min and (0.93 ± 0.35) min, respectively, and were 4.62 ± 2.3 1 and 2.35 ± 1.25 min after the treatment respectively, with significant differences (P <0.01). The IELT in experimental group was significantly different from that in control group (P <0.01). The marital status of both husband and wife: the satisfaction rate of the experimental group (62.3%) and the total satisfaction rate (satisfaction with the basic satisfaction) (89.8%) were better than the satisfaction rate of the control group (37.3%) and the total satisfaction rate of 67.2% The differences were statistically significant (P <0.01). CONCLUSIONS: Sustained low dose of vardenafil combined with trazodone and psychological behavioral therapy for premature ejaculation is significantly superior to trazodone hydrochloride combined with psychological behavioral therapy in prolonging IELT and improving the sexual life satisfaction of both spouses. Sustained low dose administration To enhance the efficacy and reduce side effects, the two drugs in the treatment of premature ejaculation have some prospects.