缩酮是一类重要的有机化合物.前人对缩酮反应的研究很多,所采用的催化剂大多数是质子酸。2,2-二甲基-4-羟甲基-1,3-二氧戊环是链状酮缩合的代表物,其制备方法的研究具有典型意义。Fischer对该化合物的合成做了多次的改进。本文使用铁盐及负载催化剂,对该化合物的制备反应进行了研究,不仅提高了产率,而且简化了实验操作。将其用于环状酮缩合代表物——螺环-1,4-二氧癸烷的制备,也取得了良好结果。 Ketal is an important class of organic compounds.Previous studies on ketal reaction are many, most of the catalyst used is protonic acid. 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane is the representative of the chain ketone condensation, the preparation of the study has a typical significance. Fischer made many improvements to the compound’s synthesis. In this paper, the use of iron salts and supported catalysts, the preparation of the compound was studied, not only improve the yield, but also simplifies the experimental operation. It was also used for the preparation of cyclic ketone condensation representatives - spiro-1,4-dioxane, and good results were also obtained.