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应用放射免疫分析法和 EL ISA法对 2 2例哮喘 ,2 2例喘支的发作期、缓解后以及 2 0例正常小儿的外周血 IL2 、SIL2 -R、IL4、IL8、TNFα、Ig E水平进行了检测。结果哮喘发作期 IL2 、SIL2 -R、IL4、IL8、TNFα、Ig E均高于正常对照 (P<0 .0 1) ,缓解后除Ig E居高不降外 ,余均明显下降。喘支患儿其变化与哮喘相类似。提示 ,上述血清非特异性炎性介质与哮喘病情变化密切相关 ,可作为哮喘病情监测的指标。喘支与哮喘可能有相似的免疫紊乱基础 ,但免疫紊乱程度不等
The levels of IL-2, SIL2-R, IL-4, IL8, TNFα, IgE in peripheral blood of 22 normal children were detected by radioimmunoassay and EL ISA after onset and remission of 22 asthmatic patients, Tested. Results The levels of IL2, SIL2-R, IL4, IL8, TNFα and IgE in asthma attack were significantly higher than those in normal control group (P <0.01). Children with asthma changes and asthma are similar. Tip, the non-specific serum inflammatory mediators and asthma is closely related to the changes in the disease, asthma can be used as indicators of disease surveillance. Asthma and asthma may have similar basis for immune disorders, but varying degrees of immune disorders