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目的:阐析药源性疾病(DID)的发病原因,即不同种类的药物,特别是中药在DID发病中的发生情况。方法:将临床诊疗中发现的58例DID住院患者的原因进行详尽调查,然后将用药与DID进行相关性分析,总结DID的发病原因。判定DID依据,排除可能的疾病因素,DID发病与用药在时间上有相关性,用药时发病或病情加重,停药病情好转或正常。结果:DID患者平均年龄67.2岁。患有1种慢性疾病的15例,患有2种以上慢性疾病的39例,共计54例,占93.1%。人均用药5.7种。用药持续时间从2d至30年。58例中有肝损害20例,消化道出血28例,共47例,占81.0%。解热镇痛药致DID共32例,占55.2%。1例DID为中药所致,占1.7%。结论:DID患者以老年多病者为多。DID调查分析其归因时要全面、慎重。解热镇痛药是DID的主要原因,中药占比不高。
Objective: To elucidate the causes of drug-induced disease (DID), that is, the occurrence of different types of drugs, especially Chinese medicine in the pathogenesis of DID. Methods: The causes of 58 inpatients with DID found in clinical diagnosis and treatment were investigated thoroughly. Then, the correlation between medication and DID was analyzed, and the etiology of DID was summarized. Judgment of DID based on the exclusion of possible disease factors, DID incidence and medication in the time-related, medication or disease aggravating, discontinuation of the disease improved or normal. Results: The average age of DID patients was 67.2 years. There were 15 cases with one chronic disease, 39 cases with two or more chronic diseases, a total of 54 cases, accounting for 93.1%. Per capita medication 5.7 species. Duration of medication from 2d to 30 years. 58 cases of liver damage in 20 cases, 28 cases of gastrointestinal bleeding, a total of 47 cases, accounting for 81.0%. Antipyretic analgesics caused a total of 32 cases of DID, accounting for 55.2%. One case of DID caused by traditional Chinese medicine, accounting for 1.7%. Conclusion: DID patients are mostly elderly and sick. DID survey analysis of its attribution should be comprehensive and careful. Antipyretic analgesics is the main reason for DID, Chinese medicine is not high.