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作者观察了50份柯萨基B组病毒（Cox B）性心肌炎患者血清IL-6、 IL-8和sIL-2R的水平变化,及与病毒血症的关系。发现病毒性心肌炎患者血清的IL-8和IL-6水平均显著高于正常对照组,其中血清Cox B抗原和特异性IgM抗体均阳性组（20例）的IL-8和IL-6含量均明显高于仅检出特异性IgM抗体组（30例）,且IL-8含量升高的程度与检测抗原的阳性强度是显著正相关。然而,两组间及与正常对照组间sIL-2R的含量均无明显差异。认为血清IL-8水平升高是病毒性心肌炎急性期的一个重要指标,并间接反映机体处于病毒血症或病毒抗原血症。
The authors observed changes in serum levels of IL-6, IL-8 and sIL-2R in 50 patients with Cox B myocarditis and their association with viremia. The levels of IL-8 and IL-6 in the serum of patients with viral myocarditis were significantly higher than those in the normal control group. The levels of IL-8 and IL-6 in serum of patients with positive Cox B antigen and specific IgM antibody Was significantly higher than the group of only specific IgM antibodies (30 cases), and the level of IL-8 was positively correlated with the positive level of test antigen. However, there was no significant difference in sIL-2R levels between the two groups and normal controls. It is considered that elevated serum IL-8 is an important indicator of the acute phase of viral myocarditis and indirectly reflects that the body is in viremia or viral antigenemia.