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口服噻氯匹定(ticlopidine)能抑制胶原诱导的血小板血栓烷B_2(TXB_2)生成。大剂量(500mg/d)可使TXB_2生成很快降低,停药1wk后恢复正常。给小剂量(250mg/d)时TXB_2的减少出现较晚,恢复亦快。噻氯匹定对ADP诱导的血小板TXB_2生成也有显著抑制作用。噻氯匹定的抗血小板作用至少有部分与抑制花生四烯酸的代谢有关。
Oral administration of ticlopidine inhibited collagen-induced thromboxane B 2 (TXB 2) production. High-dose (500mg / d) TXB 2 can be generated quickly reduced, withdrawal 1wk returned to normal. For small doses (250mg / d) TXB_2 reduction appears late, recovery is fast. Ticlopidine also has a significant inhibitory effect on ADP-induced platelet TXB2 production. The antiplatelet effect of ticlopidine is at least partly related to the inhibition of the metabolism of arachidonic acid.