目的:探讨高压氧（HBO）治疗时机和疗程对心肺复苏（CPR）成功后脑复苏患者疗效的影响。方法:选择2015年6月至2019年6月吉林大学第一医院二部接诊的89例CPR术后行脑复苏治疗的患者。所有患者入院后即开始常规药物治疗，并于不同介入时机予以HBO治疗，所有患者均接受至少3个疗程的HBO治疗。收集患者HBO治疗不同介入时机（CPR成功后<12 h、12～72 h、4～7 d和8～21 d）、不同疗程（1、2和3个疗程）后格拉斯哥昏迷评分（GCS）和振幅整合脑电图（aEEG）评分。采用重复测量方差分析，评估HBO治疗介入时机或疗程对GCS评分和aEEG评分是否存在影响，然后采用配对样本n t检验进一步验证重复测量方差分析所得结论，评估HBO疗程或介入时机对疗效的影响。n 结果:共入选89例患者，CPR成功后<12 h、12～72 h、4～7 d和8～21 d开始HBO治疗的患者分别有8、20、33及28例。① GCS评分：重复测量方差分析（使用格林豪斯-盖斯勒校正法）显示，HBO治疗疗程对GCS评分的影响存在统计学意义（n F＝ 71.735，n P＝0.000）。HBO治疗疗程与介入时机的交互差异无统计学意义（n F＝0.455，n P＝0.817）。配对样本n t检验显示，HBO治疗前及治疗1、2、3个疗程GCS评分均数分别为3.56、4.80、5.55和6.49分，两两配对比较差异均有统计学意义（均n P<0.01）。②aEEG评分：重复测量方差分析（使用格林豪斯-盖斯勒校正法）显示，HBO治疗疗程对aEEG评分的影响存在统计学意义（n F＝96.965，n P＝0.000）。HBO治疗疗程与介入时机的交互作用差异无统计学意义（n F＝1.735，n P＝0.112）。配对样本n t检验显示，HBO治疗前及治疗1、2、3个疗程aEEG评分均数分别为1.71、2.21、2.52和3.03分，两两配对比较差异均有统计学意义（均n P<0.01）。n 结论:HBO治疗对CPR成功后患者脑复苏的疗效明显，HBO疗程越长，脑复苏效果越显著。CPR成功后21 d内，HBO治疗介入时机对患者脑复苏的疗效无明显影响。“,”Objective:To explore the effect of treatment opportunity and course of hyperbaric oxygen (HBO) on the curative effect of cerebral resuscitation patients after successful cardiopulmonary resuscitation (CPR).Methods:Eighty-nine patients who underwent cerebral resuscitation after CPR admitted to the second department of the First Hospital of Jilin University from June 2015 to June 2019 were enrolled. All patients underwent conventional drug therapy after admission, and HBO therapy was added on the basis of conventional drug therapy at different intervention times, and all patients received at least 3 courses of HBO treatment. Glasgow coma scale (GCS) score and amplitude-integrated electroencephalography (aEEG) score on different treatment opportunity (i.e. intervention of HBO within 12 hours, 12-72 hours, 4-7 days, 8-21 days after successful CPR) and different course of HBO (i.e. 1, 2 and 3 courses of treatment) were recorded. Repeated measurement analysis of variance was used to assess whether the treatment opportunity or course of treatment affects the GCS score and aEEG score. Then, paired sample n t test was used to further analyze the results of repeated measurement analysis of variance and evaluate the specific effect of treatment course or intervention time on the efficacy.n Results:A total of 89 patients were enrolled. 8, 20, 33 and 28 patients started HBO treatment at < 12 hours, 12-72 hours, 4-7 days and 8-21 days after successful CPR. ① GCS score: repeated measurement analysis of variance (the Greenhouse-Geisser correction method was used) showed that the effect of course of HBO treatment on GCS score was statistically significant ( n F = 71.735, n P = 0.000). The interaction between the duration of HBO treatment and the timing of intervention was not statistically significant (n F = 0.455, n P = 0.817). Paired sample n t test showed that the means of GCS scores before HBO treatment and treatment 1, 2, 3 courses were 3.56, 4.80, 5.55 and 6.49 respectively, and the difference of pairwise pairing between different groups were statistically significant (all n P < 0.01). ②aEEG score: repeated measurement analysis of variance (the Greenhouse-Geisser correction method was used) showed that the effect of course of HBO treatment on aEEG score was statistically significant ( n F = 96.965, n P = 0.000).The interaction between the duration of HBO treatment and the timing of intervention was not statistically significant (n F = 1.735, n P = 0.112). Paired sample n t test showed that the means of aEEG scores before HBO treatment and treatment 1, 2, 3 courses were 1.71, 2.21, 2.52 and 3.03 respectively (all n P < 0.01).n Conclusions:The effect of HBO on cerebral resuscitation after CPR is obvious. The longer the course of HBO is, the more significant the effect of cerebral resuscitation is. Within 21 days after successful CPR, the treatment opportunity of HBO had no significant effect on the effect of cerebral resuscitation.