研究Ｒｂ基因产物的代谢动力学和功能调节，发现整个细胞周期中都有Ｒｂ蛋白合成，其含量随细胞周期进行而变化，蛋白代谢的半衰期约为１１—１２小时，有非磷酸化和多种程度磷酸化形式。Ｒｂ蛋白的磷酸化水平是随细胞周期过程和细胞生长状态而变化的，在Ｇ０、Ｇ１期蛋白处于低磷酸化状态，到达Ｇ１／Ｓ界限，细胞获得磷酸化Ｒｂ蛋白的能力． Rb gene products to study the metabolic dynamics and functional regulation and found that the entire cell cycle have Rb protein synthesis, its content changes with the cell cycle and protein metabolism of the half-life of about 11-12 hours, non-phosphorylated and a variety of Degree Phosphorylated form. The level of phosphorylation of Rb protein changes with the cell cycle process and the cell growth state. At the G0 and G1 phases, the protein is in a hypophosphorylated state and reaches the G1 / S boundary. The cells acquire the ability to phosphorylate the Rb protein.