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目的 探讨新生儿心肺复苏（ＣＰＲ） 时肾上腺素的最佳用药浓度及剂量。方法 ３８ 例新生儿ＣＰＲ病例，按静注肾上腺素的不同用药浓度和剂量归类为Ａ、Ｂ、Ｃ三组。Ａ 组用１ ：１ ０００ 肾上腺素０－０１ ～０－０３ ｍｇ／ｋｇ；Ｂ组，即大剂量组，用１：１ ０００ 浓度０－１～０－２ ｍｇ／ｋｇ；Ｃ组，即常规浓度剂量组，用１：１０ ０００ 浓度０－０１ ｍｇ／ｋｇ。对照分析三组肾上腺素首剂有效率、短期存活率和长期存活率的差异。结果 Ａ组和Ｂ组肾上腺素首剂有效率均明显高于Ｃ组（χ２１ ＝４－９９，χ２２ ＝６－１４，Ｐ＜ ０－０５） ，而在Ａ、Ｂ两组间无统计学差异（χ２ ＝０－２１，Ｐ＞０－０５）。短期存活率Ａ、Ｂ两组也明显高于Ｃ组（χ２１＝ ４－８９，χ２２ ＝５－２４ ，Ｐ＜０－０５） 。长期存活率则Ａ组显著高于Ｃ组（χ２＝ ５－２４，Ｐ＜ ０－０５），Ｂ组和Ｃ组无统计学差异（χ２＝ １－５１，Ｐ＞０－０５）。结论 新生儿ＣＰＲ 时肾上腺素的最佳浓度和剂量是１：１０００ 浓度０－０１～０－０３ｍｇ／ｋｇ。
Objective To investigate the best dosage and dosage of epinephrine in neonatal cardiopulmonary resuscitation (CPR). Methods 38 cases of neonatal CPR cases, according to intravenous injection of epinephrine different drug concentrations and doses classified as A, B, C three groups. A group with 1: 1 000 epinephrine 0-01 ~ 0-03 mg / kg; B group, the high-dose group, with a 1: 1000 concentration of 0-1 ~ 0-2 mg / kg; C group, that is conventional Concentration dose group, with 1: 10 000 concentration 0-01 mg / kg. Control analysis of three groups of adrenaline first dose efficiency, short-term survival and long-term survival differences. Results The effective rates of the first dose of epinephrine in group A and group B were significantly higher than those in group C (χ21 = 4-99, χ22 = 6-14, P <0-05), but no significant difference was found between group A and group B (Χ2 = 0-21, P> 0-05). The short-term survival rates in groups A and B were also significantly higher than those in group C (χ21 = 4-89, χ22 = 5-24, P <0-05). The long-term survival rate was significantly higher in group A than in group C (χ2 = 5-24, P <0-05). There was no significant difference between group B and C (χ2 = 1-51, P> 0-05). Conclusions The optimum concentration and dosage of epinephrine in neonates with CPR is 1: 1000 concentration of 0-01 ~ 0-03mg / kg.