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建立了一种简单、快速、准确测定橡胶制婴儿奶嘴中N-亚硝基二甲胺、N-亚硝基甲乙胺、N-亚硝基二乙胺、N-亚硝基二丙胺、N-亚硝基-N-甲基苯胺、N-亚硝基吡咯烷、N-亚硝基吗啉、N-亚硝基哌啶、N-亚硝基二丁胺、N-亚硝基二苯胺、N-亚硝基二苄胺迁移量的方法.样品经人工唾液盐提取后,以二氯甲烷为萃取溶剂,通过固相萃取技术萃取试液中的N-亚硝胺,去水并浓缩后,用气相色谱-质谱仪进行检测,外标法定量.11种目标物的工作曲线线性范围均为0.1—10.0 mg.L-1,方法的定量限(S/N>10)可达0.005 mg.kg-1.应用本方法对5种婴儿奶嘴进行了测试,其中3个样品中检出了N-亚硝胺.
A simple, rapid and accurate method for the determination of N-nitroso-dimethylamine, N-nitroso-methylethylamine, N-nitrosodiethylamine, N-nitrosodipropylamine, N -nitroso-N-methylaniline, N-nitrosopyrrolidine, N-nitrosomorpholine, N-nitrosopiperidine, N-nitrosodibutylamine, Aniline, N-nitrosodibenzamide migration amount of the sample after the artificial saliva salt extraction with dichloromethane as the extraction solvent extracted by solid phase extraction N-nitrosamines, dewatering and Concentration was determined by Gas Chromatography-Mass Spectrometer (GC-MS) and quantified by external standard method.The linear range of working curve of all 11 target compounds was 0.1-10.0 mg.L-1, and the limit of quantification (S / N> 10) 0.005 mg.kg-1. Five baby nipples were tested using this method, of which N-nitrosamines were detected in three samples.