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目的观察布地奈德和地塞米松治疗儿童急性喉炎的临床疗效,并分析两种药物对患儿免疫功能的影响。方法选取2015年1月至2016年6月期间于我院就诊的80例急性喉炎患儿为研究对象,根据治疗药物的不同将患儿分为观察组(布地奈德治疗)和对照组(地塞米松治疗)各40例。比较两组的临床疗效,以及治疗前后的各项免疫指标水平。结果观察组的显效率为75.0%,显著高于对照组的50.0%(P<0.05)。治疗后观察组患儿的hs-CRP、TNF-α、IL-6、WBC水平均显著优于对照组(P<0.05)。两组患儿均无明显不良反应。结论儿童急性喉炎予以布地奈德治疗的效果优于地塞米松,对免疫功能的影响更小。
Objective To observe the clinical efficacy of budesonide and dexamethasone in the treatment of acute laryngitis in children and analyze the influence of the two drugs on the immune function in children. Methods A total of 80 children with acute laryngitis treated in our hospital from January 2015 to June 2016 were selected as the study subjects. The children were divided into the observation group (budesonide treatment group) and the control group Dexamethasone treatment) in 40 cases. The clinical efficacy of the two groups were compared, and the levels of various immune indexes before and after treatment were compared. Results The markedly effective rate in the observation group was 75.0%, which was significantly higher than that in the control group (50.0%, P <0.05). After treatment, the levels of hs-CRP, TNF-α, IL-6 and WBC in the observation group were significantly better than those in the control group (P <0.05). No significant adverse reactions in both groups of children. Conclusion The efficacy of budesonide in children with acute laryngitis is better than that of dexamethasone, which has less impact on immune function.