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急性冠状动脉综合征(ACS)患者采用经皮冠状动脉介入治疗(PCI)已经成为冠状动脉血运重建的最佳手段之一。ACS的发病与冠状动脉局部斑块病变不稳定和炎症反应有关。PCI本身可能会引起血管壁的损伤和炎症反应,进而引起心肌损伤。他汀类药物的调脂和抗炎症作用,为拓宽他汀类药物的临床应用提供了依据。近年来,在PCI围术期应用他汀类药物负荷剂量治疗受到重视,这种治疗策略应用于何种类型的冠心病更有价值,值得探讨。
Percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) has become one of the best means of coronary revascularization. The pathogenesis of ACS is related to the instability and inflammation of local plaque in coronary artery. PCI itself may cause damage to the blood vessel wall and inflammatory reactions, which in turn cause myocardial damage. The lipid-lowering and anti-inflammatory effects of statins provide the basis for broadening the clinical application of statins. In recent years, the application of statin load in PCI perioperative attention has been given to this type of coronary heart disease treatment strategy is worth more, it is worth exploring.