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惊厥是儿科临床工作中的常见症状,病因和发病机理复杂。近年来,通过多学科协作研究(包括临床小儿神经病学、神经病和神经外科学、神经化学、细胞生物学、分子遗传学等)和DNA重组、神经免疫组织化学、活体影像断层扫描等先进技术的应用,对惊厥机理已有较深入的认识。目前,惊厥机理研究在以下五个方面进展较大:(1)遗传性惊厥疾病的基因定位及DNA缺陷;(2)神经介质(neurotransmitters);(3)神经调质(neuromodulators),主要是神经肽;(4)神经元-胶质细胞的相互关系;(5)神经细胞电位的阵发性去极化转换(paroxysmal depolarizat-ion shifts)。从DNA分子水平对遗传性癫痫和惊厥疾病进行
Convulsion is a common symptom in pediatric clinical work, with complicated etiology and pathogenesis. In recent years, through multidisciplinary collaborative research (including clinical pediatric neurology, neurology and neurosurgery, neurochemistry, cell biology, molecular genetics, etc.) and DNA recombination, neuroimmunohistochemistry, living image tomography and other advanced technologies Application, the mechanism of convulsions have been more in-depth understanding. At present, the research on the mechanism of seizures has made great progress in the following five aspects: (1) genetic localization and DNA defects of hereditary convulsions; (2) neurotransmitters; (3) neuromodulators, mainly neural Peptide; (4) neuronal-glial cell interplay; (5) paroxysmal depolarizat-ion shifts. From DNA molecular level to hereditary epilepsy and convulsions disease