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目的探讨川崎病(KD)再发的临床特点及其与冠状动脉病变(CAL)的关系。方法回顾性分析本院2003年1月-2010年12月收治的22例再发KD患儿临床资料,并与其初发时的临床资料进行比较分析。并采用SPSS 11.0软件对组间比较进行统计分析。结果再发病例热程较其初发时短,差异有统计学意义[(8.0±2.3)d vs(10.1±3.1)d,P<0.05],但WBC、Hb、PLT、CRP、ESR、FIB水平与初发时比较,差异均无统计学意义(Pa>0.05)。再发病例CAL发生率较初发时增加不显著(P>0.05)。再发病例应用IVIG时间较初发时早[(6.5±1.3)d vs(8.4±2.9)d,P<0.01],而应用后退热时间与初发时比较差异无统计学意义(P>0.05)。结论 KD再发病例临床表现与初发相似,CAL发生率无显著增高,但热程较短,可能与对再发病例认识早、治疗及时有关。
Objective To investigate the clinical characteristics of Kawasaki disease (KD) recurrence and its relationship with coronary artery disease (CAL). Methods The clinical data of 22 children with recurrent KD admitted in our hospital from January 2003 to December 2010 were retrospectively analyzed and compared with the clinical data at the time of initial diagnosis. SPSS 11.0 software and statistical analysis of the comparison between groups. The results showed that the relapse fever was shorter than that of the initial onset ([8.0 ± 2.3] d vs (10.1 ± 3.1) d, P <0.05), but WBC, Hb, PLT, CRP, ESR, FIB There was no significant difference between the two groups (Pa> 0.05). Recurrent cases of CAL incidence was not significantly increased (P> 0.05). The IVIG time of the recurrent cases was earlier than that of the first onset (6.5 ± 1.3 d vs 8.4 ± 2.9 d, P <0.01), while there was no significant difference between the application of IVIG and the first episode (P> 0.05 ). Conclusions The clinical manifestations of recurrent KD cases are similar to those of primary recanalization. The incidence of CAL was not significantly higher but the thermal history was shorter. It may be related to the early diagnosis and timely treatment of recurrent cases.