Objective: To determine medication regularity external therapies of Traditional Chinese medicine of eczema by data mining. Methods: Papers were retrieved from databases Pubmed,CNKI,WF,VIP,CBM,Web of Science and Embase.From the establishment of the database to April 2020 were searched.The main points of Medication Regularity were established with Excel 2016 software;the characteristics and laws in external therapies of Traditional Chinese medicine Treatment of eczema were analyzed with the relevance rule and cluster analysis Methods in data mining technology. Results: The property and flavor of the herbs mainly used were cold,bitter,while the channel which are mostly involved included liver meridian,lung meridian and Bladder Meridian, The analysis of association rules showed that kushen and difuzi had the highest correlation.The clustering analysis figured out 7groups of the herbs. Conclusion: The study presents the common pair herbs in the treatment of external therapies of Traditional Chinese medicine of eczema, which provides the approach to syndrome differentiation and medication in clinical treatment of eczema.