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背景:研究表明溃疡性结肠炎(UC)患者发生结直肠癌的风险明显增加。目的:总结UC相关腺瘤和UC相关结直肠癌(UcCRC)的发病概况和临床病理特点。方法:选取2000年1月～2012年3月南京军区南京总医院住院确诊的UC患者603例,对其中UC相关腺瘤和UcCRC患者的性别、年龄、病程、临床症状、病理表现等临床资料进行回顾性分析经。结果:603例UC患者中,UC相关腺瘤28例,发病率为4.6%(28/603);UcCRC 4例,发病率为0.7%(4/603)。UC相关腺瘤患者的UC中位病程为3年,UcCRC患者的UC中位病程为29年。UC相关腺瘤好发部位依次为直肠/乙状结肠(16处)、降结肠(7处)、横结肠(6处)、升结肠以及回盲部(4处),UcCRC发病部位分别为升结肠(1例)、降结肠(2例)、乙状结肠(1例)。UC相关腺瘤和UcCRC的临床症状与一般UC相似。结论:UC相关腺瘤和UcCRC的发病率随UC病程的延长而增加。长期病程的UC患者应定期行结肠镜检查,对预防和早期检出结直肠癌具有积极意义。
Background: Studies have shown a marked increase in the risk of colorectal cancer in patients with ulcerative colitis (UC). Objective: To summarize the clinical and pathological features of UC-related adenomas and UC-associated colorectal cancer (UcCRC). Methods: A total of 603 UC patients admitted to Nanjing General Hospital of Nanjing Military Command from January 2000 to March 2012 were selected and their clinical data such as sex, age, course of disease, clinical symptoms and pathological manifestations of UC-related adenomas and UcCRC were analyzed. Retrospective analysis. Results: Of the 603 UC patients, UC-related adenomas were found in 28 cases (4.6%, 28/603). UcCRC was found in 4 cases with a prevalence of 0.7% (4/603). The median duration of UC in UC-associated adenomas was 3 years, and the median duration of UC in UcCRC patients was 29 years. UC-related adenomas were predominantly in the rectum / sigmoid colon (16 sites), descending colon (7 sites), transverse colon (6 sites), ascending colon and ileocecal region (4 sites) Cases), descending colon (2 cases), sigmoid colon (1 case). The clinical symptoms of UC-associated adenomas and UcCRC are similar to those of normal UC. Conclusions: The incidence of UC-associated adenomas and UcCRC increased with the duration of UC. Long-term course of UC patients should be regularly colonoscopy, prevention and early detection of colorectal cancer has a positive meaning.