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1972年6月在马尔他开始的联合化疗共治疗了201例各型病人,全都用四种药,即利福平、氨苯砜、丙硫异烟胺和异烟肼,其中后三种压在一个药片内名之为Isoprodian。1983年4月第一次复查,共查到128例多菌型病人,治疗期为5～839个月,年龄20～82岁。平均55岁,其中6例证明是少菌型,6例没有完成治疗,故实查116例,LL88例、BL22例、BB6例。复查未见临床复发;查菌发现36例阳性(31％),其中26例只有颗粒形的细菌可能为“顽固菌”(对药物敏感的休眠菌)。1986年又复查了上述有完整菌的10例,
The combined chemotherapy started in Malta in June 1972 treated 201 patients of all types, all using four drugs, rifampin, dapsone, prothiostan and isoniazid, of which the last three pressures In a pill named Isoprodian. In April 1983 the first review, found a total of 128 cases of multi-bacteria patients, the treatment period of 5 to 839 months, aged 20 to 82 years. An average of 55 years of age, of which 6 cases proved to be less bacteria, 6 cases did not complete treatment, so the actual investigation of 116 cases, LL88 cases, BL22 cases, BB6 cases. The review found no clinical relapse; check the bacteria found that 36 cases were positive (31%), of which 26 only granular-shaped bacteria may be “stubborn bacteria” (drug-sensitive sleeping bacteria). In 1986 and reviewed the above complete bacteria in 10 cases,