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本实验以模拟高原低氧的方法，探讨了低氧对大鼠体液免疫的作用，并与高原鼠免比较，体液免疫以溶血亲和IgG产生为指标。实验结果：与对照组相比，大鼠低氧10d，5km海拔抑制溶血素形成10．3％，7km海拔抑制溶血素形成21．9％；经再次免疫后又低氧10d，5km海拔抑制溶血素形成4．2％，7km海拔抑制溶血素形成4．6％，高原土著动物高原鼠兔（Ochotonacurzoniae）则不表现上述的抑制现象；大鼠经SRBC腹腔致敏2d后低氧5d和8d，未表现低氧抑制溶血素形成的作用；大鼠侧脑室给予外源性CRF（1μg／rat），可抑制溶血素形成和IgG产生，溶血素形成抑制8.6％，IgG产生抑制14．0％；7km低氧大鼠侧脑室给予CRF受体阻断剂（αhelicalCRF（9－41）50μg对低氧抑制溶血素形成有一定的阻断作用，可部分阻断低氧抑制IgG产生，使IgG产生的抑制率由24．2％提高到12．互％；大鼠腹腔注射1μgCRF对溶血素形成和IgG产生无影响；与假手术组比，大鼠在摘除双侧肾上腺后，低氧对溶血素形成仍抑制6．6％。因而，本研究认为低氧对初次和再次体液免疫均产生抑制作用，而且抑制作用发生在体液免疫的起始阶段，其抑制作用与中枢CRF升高有关。
In this experiment, hypoxia on the plateau approach to explore the effect of hypoxia on humoral immunity in rats, and compared with plateau rats, humoral immunity hemolytic affinity IgG production as an indicator. Results: Compared with the control group, the rats were inhibited by hypoxia for 10 days, the hemolysin was formed at an elevation of 5 km, and the hemolysin was formed at an altitude of 10.3 mm and 21.9%, respectively. After re-immunization, (4.2%), inhibition of hemolysin (4.6%) at altitude of 7km, and plateau indigenous animal plateau pika (Ochotonacurzoniae) did not show the above inhibition. Rats were sensitized by SRBC for 2 days and then exposed to hypoxia for 5 days and 8 days, No hypoxia was found to inhibit the formation of hemolysin. Exogenous CRF (1μg / rat) was administered into the lateral ventricle of rats to inhibit hemolysin formation and IgG production, inhibition of hemolysin formation by 8.6% and inhibition of IgG production by 14.0%. The 7-h hypoxia-induced lateral ventricle CRF receptor antagonist (αhelicalCRF (9-41) 50μg on the hypoxia inhibition of hemolysin have a certain block, can be partially blocked by hypoxia inhibit IgG production, IgG produced The inhibitory rate increased from 24.2% to 12.%. The intraperitoneal injection of 1μg of CRF had no effect on the formation of hemolysin and IgG production in rats. Compared with the sham operation group, the formation of hemolysin was induced by hypoxia in rats after bilateral adrenalectomy Still inhibit 6.6%. Thus, Ben That of the initial study of hypoxia and humoral immunity are generated again inhibited and the inhibition occurred in the initial stage of humoral immunity, the inhibition of CRF central elevated.