抗生素与蛋白结合的特性与其体外抗菌作用和临床疗效密切有关,因此是衡量抗生素的重要药理学指标之一,我们对37种国产抗生素,包括青霉素类、头孢菌素类、大环内酯类、四环素类、氯霉素、利福平、洁霉素类及磷霉素等进行了血清蛋白结合率测定,同时采用杯碟法和平衡透析法,用正常人血清进行透析。测定结果与文献报道相比。多数符合或较接近。并对影响测定结果的有关因素及抗生素蛋白结合率的临床意义进行了讨论。 Antibiotics and protein binding characteristics and in vitro antibacterial effect and clinical efficacy are closely related, and therefore is one of the important pharmacological indicators to measure antibiotics, we have 37 kinds of domestic antibiotics, including penicillins, cephalosporins, macrolides, Tetracyclines, chloramphenicol, rifampicin, lincomycin and fosfomycin serum protein binding rate determination, while using the cup plate method and the equilibrium dialysis method, with normal human serum dialysis. Measurement results compared with the literature. Mostly or closely. The clinical significance of the factors influencing the determination results and the antibiotic protein binding rate was also discussed.