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在寻找植物性肿瘤抑制剂中,曾报导长梗粗榧[Cephalotaxus harringtonia var.drupacea(Sieb.&Zucc.)Koidzumi]种子的乙醇提取物对小白鼠淋巴白血病L-1210及P-388白血病有抑制作用。作者从柱冠日本粗榧[C.harringtonia(Forbes)K.Koch var.harringtonia cv.Fastigiata.]种子和全植物的提取物中分离得到四种有明显抗癌活性的生物碱。此有效的粗榧生物碱是三尖杉碱(Cephalotaxine)(Ⅰ)的酯类,即长梗粗榧碱(Harringtonine)(Ⅱ),异长梗粗榧碱(Isoharringtonine)(Ⅲ),高长梗粗榧碱(Homoharringtonine)(Ⅳ)和脱氧长梗粗榧碱(Deoxyharringtonine)(Ⅴ)。前三种用
In the search for plant tumor suppressors, ethanol extract of Cephalotaxus harringtonia var.drupacea (Sieb. & Zucc.) Koidzumi seeds has been reported to inhibit mouse leukemia L-1210 and P-388 leukemias . The authors isolated four alkaloids with distinct anticancer activity from C.harringtonia (Forbes) K.Koch var. Harringtonia cv. Fastigiata.] Seed and whole plant extracts. This effective crude alkaloid is an ester of Cephalotaxine (I), namely, Harringtonine (II), Isoharringtonine (III), tall Homoharringtonine (IV) and Deoxyharringtonine (V). The first three used