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目的研究纳美芬联合丹参多酚酸盐治疗急性重度酒精中毒患者心肌保护作用。方法选取急诊96例急性重度酒精中毒患者随机分为治疗组(纳美芬联合丹参多酚酸盐组)和对照组(纳美芬组),每组48例。测定2组患者治疗前后心肌生化标志物(cTnI、CK、CK-MB)。结果治疗组患者治疗前后心肌生化标志物有明显变化,治疗后心肌生化标志物明显下降,差异有统计学意义(P<0.05);对照组患者治疗前后心肌生化标志物变化差异有统计学意义(P<0.05);2组治疗前心肌生化指标差异无统计学意义(P>0.05);2组治疗后心肌生化指标,治疗组明显优于对照组,差异有统计学意义(P<0.05)。结论纳美芬联合注射用丹参多酚酸盐对急性重度酒精中毒患者心肌损害有明显保护作用,且使用方便,见效快,安全性高,值得在临床推广应用。
Objective To study the myocardial protection effect of nalmefene combined with salvianolate on acute severe alcoholism. Methods A total of 96 patients with acute severe alcoholism were selected and randomly divided into treatment group (nalmefene plus salvianolate group) and control group (nalmefene group), 48 in each group. Myocardial biochemical markers (cTnI, CK, CK-MB) were measured before and after treatment in two groups. Results Before and after treatment, the biochemical markers of myocardium in treatment group were significantly changed. The biochemical markers of myocardium were significantly decreased after treatment (P <0.05). The changes of myocardial biochemical markers before and after treatment in the control group were statistically significant (P < P <0.05). There was no significant difference in myocardial biochemical parameters between the two groups before treatment (P> 0.05). The myocardial biochemical indexes in the two groups were significantly better than those in the control group after treatment (P <0.05). Conclusion nalmefene combined Salviae miltiorrhizae polyphenols for acute myocardial infarction in patients with severe alcohol poisoning has obvious protective effect, and easy to use, quick, safe, it is worth in the clinical application.