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目的评价左西孟旦注射液在治疗充血性心力衰竭患者中的临床疗效及安全性。方法选取重症充血性心力衰竭患者47例,随机分为观察组和对照组。对照组患者给予常规治疗:除了一般治疗外,给予洋地黄强心、利尿剂、血管扩张药、β受体阻滞剂等治疗。观察组在对照组用药基础上,静脉应用左西孟旦注射液治疗,用药前后检查超声心动图评估心功能,监测肝、肾功能,心率,血压变化、呼吸困难程度及血生化指标的变化。结果治疗后两组左室射血分数明显加强(P<0.05),临床症状及体征均有不同程度的改善,观察组总有效率与对照组比较,差异有统计学意义(P<0.05)。结论左西孟旦可使充血性心力衰竭患者射血分数提高,呼吸困难程度下降,全身状况改善。可有效地减轻心脏负荷,改善心脏收缩功能,而且患者的耐受性好,较为安全。
Objective To evaluate the clinical efficacy and safety of levosimendan injection in the treatment of patients with congestive heart failure. Methods Forty-seven patients with severe congestive heart failure were randomly divided into observation group and control group. Control group of patients given conventional treatment: In addition to the general treatment, giving digitalis concen- trate, diuretics, vasodilators, β-blockers and other treatments. The observation group was treated with levosimendan intravenously on the basis of the control group. Echocardiography was used to evaluate the cardiac function before and after treatment. The changes of liver and kidney function, heart rate, blood pressure, degree of dyspnea and blood biochemical parameters were monitored. Results After treatment, left ventricular ejection fraction was significantly enhanced (P <0.05), clinical symptoms and signs were improved to varying degrees, the total effective rate of the observation group compared with the control group, the difference was statistically significant (P <0.05). Conclusion Levosimendan can improve the ejection fraction, the degree of dyspnea and the general condition in patients with congestive heart failure. Can effectively reduce the heart load, improve systolic function, and patient tolerance is good, safer.