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目的探讨多重耐药菌感染在急性胰腺炎病程中的影响。方法对华西医院2009年1月至2012年6月期间收治的134例胰腺坏死组织感染患者的临床资料进行回顾性分析。结果 134例患者中,为多重耐药菌感染者78例,非多重耐药菌感染者56例。外院转入共36例,其中多重耐药组转入者比例较非耐药组高(38.5%比10.7%,P=0.002)。多重耐药组患者的死亡率(20.5%比14.3%)及总住院时间(78 d比55 d)与非耐药组比较差异均无统计学意义(P>0.05);但多重耐药组患者ICU住院者比例较非耐药组高(48.7%比26.8%,P=0.01),且多重耐药组患者住ICU时间较非耐药组长(20 d比3 d,P<0.001)。结论多重耐药菌感染在坏死性胰腺炎患者尤其是转入患者当中的发生率较高,且其对患者ICU住院比例及住ICU时间的影响不能忽视。
Objective To investigate the influence of multiple drug-resistant bacterial infection in the course of acute pancreatitis. Methods A retrospective analysis was performed on the clinical data of 134 cases of pancreatic necrosis tissue infection admitted to West China Hospital from January 2009 to June 2012. Results Of the 134 patients, 78 were multi-drug resistant and 56 were non-multi-drug resistant. A total of 36 cases were transferred from outside hospitals, of which the proportion of those who received multi-drug resistance was higher than that of non-drug-resistant patients (38.5% vs. 10.7%, P = 0.002). There was no significant difference in mortality rate (20.5% vs. 14.3%) and total hospital stay (78 days vs 55 days) in non-drug group compared with non-drug group (P> 0.05) The proportion of hospitalized patients in ICU was higher than that in non-drug-resistant patients (48.7% versus 26.8%, P = 0.01). ICU patients in multi-drug resistant patients lived longer than non-drug resistant ones (20 days vs 3 days, P <0.001). Conclusion The incidence of multi-drug resistant bacterial infection in patients with necrotizing pancreatitis, especially into patients is high, and its impact on ICU hospitalization and ICU stay can not be ignored.