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[目的]分析肿瘤患者红细胞输注无效的相关因素,为临床肿瘤患者科学、有效的输血提供依据。[方法]回顾性分析2014年1月至2016年4月衢州市柯城区人民医院485例肿瘤患者红细胞输注无效与相关因素之间的关系,分析输血不良反应发生率与输血效果的关联性。用Logistic回归分析可能影响肿瘤患者红细胞输注无效的因素。[结果]肿瘤患者红细胞输注无效比例为21.65%(105/485)。单因素分析显示肿瘤患者红细胞输注无效与既往输血次数、既往输血量及妊娠次数密切相关;迟发型溶血反应的发生率与肿瘤患者红细胞输注效果密切相关。Logistic回归分析显示多次输血(OR=8.48,P=0.00)是肿瘤患者红细胞输注无效的独立危险因素。[结论]有多次输血史的肿瘤患者发生红细胞输注无效的风险较高。针对有反复输血史的肿瘤患者,应制定独立、安全、有效的个体化输血策略。
[Objective] To analyze the related factors of ineffective erythrocyte infusion in cancer patients and provide basis for scientific and effective blood transfusion in clinical cancer patients. [Methods] The relationship between the ineffective erythrocyte infusion and related factors in 485 cancer patients of Quzhou City People’s Hospital from January 2014 to April 2016 was retrospectively analyzed. The association between the incidence of transfusion adverse reactions and blood transfusion was analyzed. Logistic regression analysis of factors that may affect the ineffectiveness of erythrocyte infusion in cancer patients. [Results] The ratio of ineffective erythrocyte infusion in cancer patients was 21.65% (105/485). Univariate analysis showed that the ineffective erythrocyte infusion in tumor patients was closely related to the number of transfusions, previous transfusions and the number of pregnancies. The incidence of delayed hemolysis was closely related to the effect of erythrocyte infusion on tumor patients. Logistic regression analysis showed that multiple transfusions (OR = 8.48, P = 0.00) were independent risk factors for ineffective erythrocyte infusion in cancer patients. [Conclusions] Tumor patients with multiple blood transfusions have a higher risk of ineffective erythrocyte infusion. For patients with recurrent blood transfusion should develop independent, safe and effective individualized blood transfusion strategy.