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采用ＡＢＣ免疫组化法观察了４５例各类型肺癌和８例炎性肺组织中铜锌超氧化物歧化酶的定位，以正常支气管作对照。染色结果显示：①单纯炎症和伴鳞化的炎症以及小细胞肺癌时，细胞中Ｃｏｐｐｅｒ－ＺｉｎｃｓｕｐｅｒｏｘｉｄｅＤｉｓｍｕｔａｓｅ（ＣｕＺｎＳＯＤ）染色阴性；②鳞癌中６６％（１０／１５）的病例染色仅为细胞浆阳性，而核阴性，占本组阳性病例的８３．３％（１０／１２），明显高于其他病变组（χ２检验Ｐ＜０．０５）；③肺腺癌ＣｕＺｎＳＯＤ染色阳性率５２．９４％，弱阳性居多；④浆液腺ＣｕＺｎＳＯＤ染色强阳性，呈颗粒样，无病种特异性；⑤燕麦细胞癌与大细胞癌组织中ＣｕＺｎＳＯＤ染色为核、浆双着色
The location of copper-zinc superoxide dismutase in 45 cases of lung cancer and 8 cases of inflammatory lung tissues were observed by ABC immunohistochemistry. Normal bronchus was used as a control. The results of staining showed that: 1) In the case of inflammation of simple inflammation and squamose and small cell lung cancer, the staining of Copper-ZincsuperoxideDismutase (CuZnSOD) was negative in the cells; (2) Staining was only cytoplasm in 66% (10/15) cases of squamous cell carcinomas. Positive and nuclear negative, accounting for 83.3% (10/12) of this group of positive cases, significantly higher than other lesions (χ2 test P <0.05); 3 lung adenocarcinoma CuZnSOD staining positive rate 52.94% , weak positive majority; 4 serous gland CuZnSOD staining strong positive particle-like, no disease-specific; 5 Oat cell carcinoma and large cell carcinoma in CuZnSOD staining for nuclear, pulp double coloring