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目的了解对氨基水杨酸异烟肼(PSNZ)对耐异烟肼(INH)及对氨基水杨酸钠(PAS)的结核菌株耐药情况。方法用改良罗氏培养基观察36株同时耐INH和PAS及149株对INH和PAS敏感的结核菌株对PSNZ药敏结果。结果 36株耐INH和PAS的结核菌株在1μg/ml浓度下有44.4%的菌株对PSNZ有效，149株对INH和PAS均敏感的结核菌株在1μg/ml浓度下有96%的结核菌株对PSNZ敏感。结论 PSNZ对耐INH和／或PAS的结核菌株仍显示一定程度的敏感，是一种独立的抗结核药物，可作为治疗耐多药结核病的有效药物之一。“,”Objective To determine the PSNZ drug resistance incidence among INH and PAS-resistant M.tuberculosis.Methods By applying the reformed L-J medium, observe and compare the drug-resistance and drug-susceptibility to PSNZ in 36 INH and PAS resistant-M. tuberculosis, and 149 INH and PAS sensitive M. tuberculosis.Results 44.4% of the 36 INH and PAS resistant-M. tuberculosis are susceptible to PSNZ at the concentration of 1μg/ml; 96% of the 149 INH and PAS sensitive M. tuberculosis are susceptible to PSNZ at the concentration of 1μg/ml.Conclusion PSNZ is still effective to some of the TB bacteria resistant to INH and/or PAS. It is an independent anti-TB drug. It can be used as one of the effective drugs for treat the MDR-TB.