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目的：为探讨Ｌ－精氨酸（Ｌ－Ａｒｇ）对异丙肾上腺素（ＩＳＰ）致害心肌的影响。方法：将大鼠随机分为４组：ＩＳＰ组，ＩＳＰ４０ｍｇ／ｋｇ·ｄａｙ×２，皮下注射；对照组，体重匹配的大鼠注射同容量的生理盐水；Ｌ－Ａｒｇ组腹腔注射Ｌ－Ａｒｇ１．５ｇ／ｋｇ·ｄ×２；ＩＳＰ＋Ｌ－Ａｒｇ组。结果：ＩＳＰ处理的大鼠心重／体重比值、心肌内ＮＯ、钙的水平以及血清ＬＤＨ、ＮＯ水平高于对照组（ｐ＜０．０５），而心肌中ＧＳＨ－ＰＸ及Ｌ－Ａｒｇ水平低于对照组（ｐ＜０．０５），Ｌ－Ａｒｇ可部分逆转ＩＳＰ致心肌肥厚，心肌中ＮＯ、钙、Ｌ－Ａｒｇ、ＧＳＨ－ＰＸ及血清ＬＤＨ、ＧＳＨ－ＰＸ水平的变化。结论：Ｌ－Ａｒｇ对ＩＳＰ致害心肌有抗损伤的作用。
Objective: To investigate the effect of L-arginine on myocardial damage induced by isoproterenol (ISP). Methods: The rats were randomly divided into 4 groups: ISP group, ISP40mg / kg · day × 2, subcutaneous injection; control group, body weight matched rats injected with the same volume of saline; L-Arg group intraperitoneal injection of L-Arg1. 5g / kg · d × 2; ISP + L-Arg group. Results: Compared with the control group, the levels of NO and calcium in myocardium and the level of serum LDH and NO in ISP-treated rats were significantly lower than those in control group (P <0.05), while the levels of GSH-PX and L-Arg in myocardium were lower L-Arg could partially reverse the changes of myocardial hypertrophy, myocardial NO, Ca, L-Arg, GSH-PX, serum LDH and GSH-PX levels in the control group (p <0.05) Conclusion: L-Arg has an anti-injury effect on ISP-induced myocardial injury.