The existing traditional methods of assessing the rates of soil loss have many limitations and are difficult to apply in the karst areas of Southwest China. Karst depressions comprise geomorphologically important sources and sinks for sediments and associated pollutants, yet the sedimentology of many depressions is not well understood. In this paper, the 137Cs technique was employed to investigate recent sedimentation rates in a Chinese polygonal karst depression. The results indicated that the sediment consistent with the local monitoring data of runoff plots, confirming the validity of the overall approach. It was shown that soil loss rates were very low in some karst areas of Southwest China. Above all, the approach appears to offer valuable potential to study surface erosion by estimating sediment deposition rates of karst depressions, rather than the assessment of complicated soil erosion in stony soils of carbonate rock slopes. In addition, the spacial distribution of surface soil and 137Cs inventories was affected remarkably by the inhomogeneous dissolution of limestone under the soil. It may be an important phenomenon which exists widely in the karst areas and is significantly different from other places.