目的:研究黄芪注射液联用丹参酮ⅡA磺酸钠注射液对单侧输尿管梗阻(UUO)模型大鼠肾脏骨形态发生蛋白7(BMP-7)及其受体(BMPR-Ⅰa)和Smad5的表达影响。方法:36只清洁级雄性SD大鼠随机分为假手术组、模型组和治疗组,在术后14和28 d分批处死动物。HE和Masson染色观察肾形态变化,实时荧光定量PCR和免疫组化检测BMP-7及其受体和Smad5的 Objective: To investigate the effect of Astragalus injection combined with sodium tanshinone Ⅱ A sulfonate on the expression of BMP-7, BMPR-Ⅰa and Smad5 in rats with unilateral ureteral obstruction (UUO) influences. Methods: Thirty-six male Sprague-Dawley rats were randomly divided into sham-operation group, model group and treatment group. Animals were sacrificed at 14 and 28 days after operation. The morphological changes of kidney were observed by HE and Masson staining, and the expression of BMP-7 and its receptor and Smad5 were detected by real-time fluorescence quantitative PCR and immunohistochemistry