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目的观察MMP9、hs-CRP、BNP、S-100和DD在急性缺血性脑卒中前的诊断价值。方法选取入院时临床上怀疑AIS的患者99例,检测MMP9、hs-CRP、BNP、S-100和DD水平,以影像学的结果为金标准,探讨相应指标的诊断价值。结果 AIS组患者的MMP9、hs-CRP、BNP、S-100和DD明显升高,均值分别为(2.01±0.71)ug/L、(5.54±1.21)mg/L、(5.71±1.48)ng/L、(134.41±68.34)ng/L和(2.95±0.45)mg/L。临界值分别为0.15ug/L、0.85mg/L、0.66ng/L、15.6ng/L和0.35mg/L。结论 MMP9和S-100对AIS具有诊断意义,该研究对于早期发现脑梗死前状态的患者具有重要意义。
Objective To observe the diagnostic value of MMP9, hs-CRP, BNP, S-100 and DD before acute ischemic stroke. Methods Ninety-nine patients with clinically suspected AIS on admission were enrolled in this study. The levels of MMP9, hs-CRP, BNP, S-100 and DD were detected. The diagnostic value of the corresponding indexes was explored using the imaging results as the gold standard. Results The levels of MMP9, hs-CRP, BNP, S-100 and DD in AIS group were significantly higher than those in the control group (mean 2.01 ± 0.71 ug / L, 5.54 ± 1.21 mg / L, (134.41 ± 68.34) ng / L and (2.95 ± 0.45) mg / L, respectively. The critical values were 0.15ug / L, 0.85mg / L, 0.66ng / L, 15.6ng / L and 0.35mg / L, respectively. Conclusions MMP9 and S-100 are of diagnostic value for AIS. This study is of great significance for early detection of patients with pre-infarction status.