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目的探讨妇科晚期恶性肿瘤术中行双侧髂内动脉化疗对妇科恶性肿瘤治疗的价值。方法回顾性分析内蒙古民族大学附属医院1997年10月至2007年10月共189例妇科晚期恶性肿瘤患者,其中术中行双侧髂内动脉灌注化疗者(实验组)共96例,常规采取腹腔内灌注化疗者(对照组)共93例。结果髂内动脉化疗组较对照组在手术时间、切口愈合情况、术后感染、消化道反应及术后肝肾功能改变等方面无明显差异;术后同期CEA、CA125较对照组明显降低,差异有统计学意义(P<0.05);卵巢癌患者术后腹水引出量实验组明显低于对照组,差异有统计学意义(P<0.05)。结论妇科晚期恶性肿瘤患者行术中髂内动脉灌注化疗安全、有效,并能有效的控制腹水,优于腹腔灌注化疗。
Objective To investigate the value of bilateral internal iliac artery chemotherapy for the treatment of gynecologic malignancies during the operation of advanced gynecologic malignant tumors. Methods A retrospective analysis of 189 patients with advanced gynecological cancer from October 1997 to October 2007 in the Affiliated Hospital of Inner Mongolia University for Nationalities was performed. Among them, 96 patients underwent bilateral internal iliac artery infusion chemotherapy (experimental group) during operation. Conventional intraperitoneal Perfusion chemotherapy (control group) a total of 93 cases. Results Compared with the control group, the internal iliac artery chemotherapy group had no significant differences in the operation time, incision healing, postoperative infection, gastrointestinal reaction and postoperative liver and kidney function changes; CEA and CA125 in the same period after operation were significantly lower than those in the control group, (P <0.05). The ascites volume in ovarian cancer patients was obviously lower than that in control group (P <0.05). Conclusion The patients with advanced gynecologic malignant tumors underwent intra-artial internal iliac arterial infusion chemotherapy safely and effectively, and can effectively control ascites and is superior to intra-peritoneal perfusion chemotherapy.