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目的了解眼镜蛇毒制剂新克痛宁对术后镇痛效果。方法对７２例胫腓骨折病人，在连续硬膜外阻滞麻醉下行切开复位内固定术，术后随机分为４组（每组１８例）向硬膜外腔注药：Ａ组新克痛宁０．２５ＩＵ／ｋｇ；Ｂ组新克痛宁０．１２５ＩＵ／ｋｇ加０．５％利多卡因液１０ｍｌ；Ｃ组吗啡２ｍｇ；Ｄ组吗啡１ｍｇ加０．５％利多卡因液１０ｍｌ。结果镇痛持续时间Ａ、Ｂ组明显延长，Ａ与Ｂ组分别为（４１２±２８）ｍｉｎ，与Ｃ、Ｄ组比较差异显著（Ｐ＜０．０５）。注药后３０～１２０ｍｉｎ，患肢足背皮肤温度，Ａ、Ｂ组亦高于Ｃ、Ｄ组（Ｐ＜０．０５），且无不良反应。结论新克痛宁术后镇痛效果比吗啡好。
Objective To understand the cobra venom preparation Xin Ke Tong Ning on postoperative analgesia. Methods Seventy-two patients with tibiofibular fractures underwent open reduction and internal fixation under continuous epidural anesthesia. The patients were randomly divided into 4 groups (18 in each group) Tong Ning 0.25IU / kg; B group new Ke Tong Ning 0.125IU / kg plus 0.5% lidocaine solution 10ml; C morphine 2mg; D morphine 1mg plus 0.5% lidocaine solution 10ml. Results The lasting duration of analgesia was prolonged in group A and group B, which was (412 ± 28) min in group A and group B, respectively, which was significantly different from group C and D (P <0.05). After 30 ~ 120min injection, the temperature of the skin of the instep dorsal foot was also higher in groups A and B than in groups C and D (P <0.05), and no adverse reactions were found. Conclusion New Ketong Ning postoperative analgesic effect is better than morphine.