论文部分内容阅读
本文对88例慢性肾脏病患者肌酐清除率(Ccr)、血清β_2微球蛋白(Sβ_2MG)、尿渗压(Uosm)/血浆渗压(Posm)及24小时尿蛋白定量(UP)/尿β_2微球蛋白(Uβ_2MG)进行了测定。按不同Ccr及Uosm/Posm比值各分4组,结果显示:随Ccr逐渐降低,UP/Uβ_2pMG比值亦渐缩小,在尿毒症期呈显著性缩小(P<0.01);随UP/Uβ_2MG比值逐渐减小,Uosm/Posm比值亦呈递减规律,在Uosm/Posm比值为1.5—2时,与UP/Uβ_2MG比值及Ccr均呈显著性正相关(P<0.01)。表明在慢性肾脏病时肾小管功能损害是造成进行性肾小球损害的重要因素。
In this study, 88 patients with chronic kidney disease were evaluated for creatinine clearance (Ccr), serum β_2 microglobulin (Sβ_2MG), urinary osmotic pressure (Uosm) / plasma osmolality (Posm), and urine / Globulin (Uβ_2MG) was measured. According to the ratio of Ccr and Uosm / Posm, there were 4 groups in each group. The results showed that with the decrease of Ccr, UP / Uβ_2pMG ratio also decreased and decreased significantly during uremia (P <0.01) The ratio of Uosm / Posm also showed a decreasing rule. When Uosm / Posm ratio was 1.5-2, there was a significant positive correlation with UP / Uβ_2MG ratio and Ccr (P <0.01). Indicate that renal tubular dysfunction during chronic kidney disease is an important cause of progressive glomerular damage.