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特应性皮炎(AD)是慢性复发性炎症性皮肤病.已有大量研究表明,嗜酸性粒细胞(EOS)与AD发病有重要关联.EOS主要在由Th2细胞介导的免疫反应分泌的细胞因子和趋化因子的作用下,活化、分化和增长,从骨髓和血液中迁移到真皮层,分泌颗粒蛋白、细胞因子等炎症递质,造成胶原沉积和皮肤增厚等改变.文章概述了EOS在AD发病中的主要作用与机制,以期对AD的发病有更深入的认识,也望对新药研发提供思路.“,”Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin disease. Multiple studies have demonstrated a significant correlation between the eosinophil (EOS) and AD. Th2 cells secret cytokines and chemokines mediating the activation, differentiation and growth of EOS. EOS is recruited from bone marrow and blood into the dermis, and releases granule proteins, cytokines etc., resulting in the deposition of collagen and fibrosis thickening. This article reviews the recent studies of the main role and mechanism of EOS in the pathogenesis of AD, aiming to a further understanding of this disease and provides insights for the development of new drugs.