Ciprofloxacin 是一类可穿入细胞内的喹啉类药物,在体外试验显示出抗羊种布氏菌的活性。本文应用 Ciprofloxacin 和四环素治疗小鼠羊种和牛种布氏菌感染。分别在感染后第7、14、21和28天给药,实验表明四环素可降低肝重、脾重以及脾菌数,经3～4周治疗,70%的小鼠可消除感染。相反,经同样 Ciprofloxacin, a class of quinolines that penetrate cells, showed in vitro activity against B. lamblia. In this paper, Ciprofloxacin and tetracycline were used to treat mice and Brucella bovine infection. Were administered on the 7th, 14th, 21st and 28th day after infection, respectively. Experiments show that tetracycline can reduce liver weight, spleen weight and spleen number. After 3 to 4 weeks of treatment, 70% of the mice can eliminate the infection. On the contrary, the same