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目的通过对社区65岁以上老年甲状腺功能减退症患者进行分析,引起医务人员及老年人对甲状腺功能减退症的重视,提高老年患者的生活质量。方法收集2011年2月到2012年12月社区自愿参与调查的65岁以上老年甲状腺功能减退症患者120例为实验组,另外选择同期正常健康体检老年人120例为对照组,测定两组患者血清中胰岛素样生长因子-1(IGF-1)、白细胞介素-8(IL-8)水平。并采用韦氏记忆量表(WMS)和简明精神状态检查表(MMSE)评分测试两组患者的认知功能水平。结果实验组患者血清中IGF-1、IL-8水平明显降低,与对照组比较差异有统计学意义(P<0.05)。实验组患者WMS及MMSE评分明显降低,与对照组比较差异有统计学意义(P<0.05)。结论老年甲状腺功能减退症患者血清中IGF-1、IL-8水平明显降低,并且存在认知功能障碍。
Objective To analyze the elderly patients with hypothyroidism over the age of 65 in the community, causing the medical staff and the elderly to pay more attention to the hypothyroidism and improve the quality of life in the elderly. Methods A total of 120 elderly patients with hypothyroidism over 65 years of age from February 2011 to December 2012 were selected as the experimental group and another 120 healthy elderly controls were selected as the control group. Serum Insulin-like growth factor-1 (IGF-1), interleukin-8 (IL-8) levels. The WMS and MMSE scores were used to test the cognitive function of the two groups. Results The levels of serum IGF-1 and IL-8 in the experimental group were significantly lower than those in the control group (P <0.05). The scores of WMS and MMSE in the experimental group were significantly lower than those in the control group (P <0.05). Conclusion Serum levels of IGF-1 and IL-8 in elderly patients with hypothyroidism are significantly lower, and cognitive dysfunction exists.