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目的探讨胰岛素样生长因子结合蛋白-2(insulinlike growth factor binding protein-2,IGFBP-2)在肺腺癌组织中的表达及意义。方法应用免疫组化法检测了50例肺腺癌以及相应癌旁肺组织中IGFBP-2的表达情况,并分析其与相关临床病理参数的关系。结果肺腺癌组织及相应癌旁肺组织中IGFBP-2的阳性率分别为74%、8%,差异有统计学意义(P<0.01)。与高、中分化的肺腺癌相比,低分化肺腺癌IGFBP-2阳性表达的比例明显较高,两者之间的差异具有统计学意义(P<0.05)。此外,与不伴淋巴结转移的肺腺癌相比,在伴有淋巴结转移的肺腺癌中IGFBP-2阳性表达的比例明显较高,两者之间的差异具有统计学意义(P<0.05)。结论 IGFBP-2在肺腺癌组织中有较高表达且与分化较差及淋巴结转移相关,表明其在肺腺癌的发生、发展及转归过程中可能具有一定的意义。
Objective To investigate the expression and significance of insulin like growth factor binding protein-2 (IGFBP-2) in human lung adenocarcinoma. Methods Immunohistochemistry was used to detect the expression of IGFBP-2 in 50 cases of lung adenocarcinoma and its corresponding paracancer lung tissue. The relationship between IGFBP-2 and related clinicopathological parameters was analyzed. Results The positive rates of IGFBP-2 in lung adenocarcinoma tissues and corresponding adjacent lung tissues were 74% and 8%, respectively, with statistical significance (P <0.01). The proportion of IGFBP-2 positive cells in poorly differentiated lung adenocarcinomas was significantly higher than that in high and moderately differentiated lung adenocarcinomas (P <0.05). In addition, compared with lung adenocarcinoma without lymph node metastasis, the positive rate of IGFBP-2 in lung adenocarcinoma with lymph node metastasis was significantly higher than that without lymph node metastasis (P <0.05) . Conclusions IGFBP-2 is highly expressed in lung adenocarcinoma and is associated with poorly differentiated and lymph node metastasis, suggesting that IGFBP-2 may play a role in the development, progression and prognosis of lung adenocarcinoma.