目的观察贝尼地平联合氢氯噻嗪对老年高血压病患者降压作用的稳定性及其对左室舒张功能的影响。方法老年原发性高血压56例,年龄60～82岁,随机分为两组。A组27例,口服复方降压片及氢氯噻嗪片;B组29例,应用贝尼地平联合氢氯噻嗪治疗。两组均连续用药8周,用动态血压和超声心动图分别监测血压和进行左室舒张功能观察。结果降压疗效总有效率A组为81.5%(22例),B组为86.2%(25例),两组比较,差异无统计学意义(P>0.05)。但反映血压起伏变化的血压变异率和血压负荷,用药后与用药前相比,A、B组差异性均有统计学意义(P<0.05),且B组更显著,B组治疗后与A组治疗后相比,P<0.05。左室舒张功能各项指标,A、B组两组治疗前后比较均差异有统计学意义(P<0.05和P<0.01),且B组左室舒张功能各项指标改善程度优于A组(P<0.05)。治疗期间未见严重不良反应。结论贝尼地平联合氢氯噻嗪对老年高血压病患者具有稳定的降压作用,且有改善左室舒张功能的作用。 Objective To observe the stability of antihypertensive effect of benidipine combined with hydrochlorothiazide in elderly patients with hypertension and its effect on left ventricular diastolic function. Methods 56 cases of senile essential hypertension, aged 60 to 82 years old, were randomly divided into two groups. A group of 27 cases, oral compound antihypertensive tablets and hydrochlorothiazide tablets; B group 29 cases, the application of benidipine combined with hydrochlorothiazide treatment. Both groups were continuously treated for 8 weeks, using ambulatory blood pressure and echocardiography to monitor blood pressure and left ventricular diastolic function were observed. Results The total effective rate of antihypertensive effect in group A was 81.5% (22 cases) and group B was 86.2% (25 cases). There was no significant difference between the two groups (P> 0.05). However, the variation of blood pressure and the variation of blood pressure reflected the changes of blood pressure. After treatment, the difference between groups A and B was statistically significant (P <0.05), and the difference was significant between group B and group A Group after treatment compared to P <0.05. The indices of left ventricular diastolic function in group A and group B were significantly different before and after treatment (P <0.05 and P <0.01), and the indexes of left ventricular diastolic function in group B were better than those in group A P <0.05). No serious adverse reactions during treatment. Conclusion Benidipine combined with hydrochlorothiazide has a steady antihypertensive effect on elderly patients with hypertension and has the effect of improving left ventricular diastolic function.