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目的探讨血脂异常和胰岛素抵抗与老年糖尿病大血管病变的关系。方法测定４６例老年Ⅱ型糖尿病（包括２６例伴大血管病变）患者血糖、胰岛素和脂质水平。结果总胆固醇（ＴＣ）、甘油三酯（ＴＧ）显著增高而高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）显著降低。糖尿病伴大血管病变患者这些改变更为显著，且伴高胰岛素血症及明显的胰岛素抵抗、胰岛素敏感性指数（ＩＡＩ）与体重指数（ＢＭＩ）、ＴＣ、ＴＧ呈负相关，与ＨＤＬ－Ｃ呈正相关。结论胰岛素抵抗，血脂异常、动脉粥样硬化之间，有着密切联系。
Objective To investigate the relationship between dyslipidemia and insulin resistance and macrovascular complications in elderly patients with diabetes mellitus. Methods Blood glucose, insulin and lipid levels were measured in 46 elderly patients with type 2 diabetes mellitus (including 26 with major vascular disease). Results Total cholesterol (TC), triglyceride (TG) increased significantly and HDL-C decreased significantly. These changes were more significant in diabetic patients with macrovascular complications, with hyperinsulinemia and obvious insulin resistance, insulin sensitivity index (IAI) and body mass index (BMI), TC, TG was negatively correlated with HDL-C positive Related. Conclusion There is a close relationship between insulin resistance, dyslipidemia and atherosclerosis.