喹诺酮类属化学合成抗菌药,由于该类药物具有吡啶酮的基本结构而命名,目前该类药物是抗菌药物中发展最快、应用最广的一类药物。这一类药物,从结构上是7位上连一个哌嗪环,6位处又引入氟原子。主要特点是:①广谱性:对G~-和G~+杆菌均有强大的抗菌作用,特别是绿脓杆菌等多种耐药菌仍可对该类药物呈现敏感。②口服吸收好:给药后吸收快,药物浓度在较长时间内在有效浓度以上,有效地发挥了体内抗菌活性。③在组织和体液中分布广。④毒性反应低,用药安全。喹诺酮类药物主要作用是抑制细菌DNA合成回 Quinolones are chemically synthesized antibacterials. Since these drugs are named after the basic structure of pyridone, these drugs are currently the fastest growing and most widely used class of antimicrobial drugs. This class of drugs, from the structural position is a piperazine ring 7, 6 and the introduction of fluorine atoms. The main features are: ① broad spectrum: G ~ - and G ~ + bacteria have a strong antibacterial effect, in particular, Pseudomonas aeruginosa and other resistant bacteria can still be sensitive to these drugs. ② oral absorption is good: fast absorption after administration, the drug concentration in a longer period of time above the effective concentration, effectively play an in vivo antibacterial activity. ③ widely distributed in tissues and body fluids. ④ low toxicity, medication safety. The main role of quinolones is to inhibit bacterial DNA synthesis back